Journal article
Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease
DJ Campbell, JB Somaratne, AJ Jenkins, DL Prior, M Yii, JF Kenny, AE Newcomb, CG Schalkwijk, MJ Black, DJ Kelly
Cardiovascular Diabetology | Published : 2011
Abstract
Background: Type 2 diabetes and the metabolic syndrome are associated with impaired diastolic function and increased heart failure risk. Animal models and autopsy studies of diabetic patients implicate myocardial fibrosis, cardiomyocyte hypertrophy, altered myocardial microvascular structure and advanced glycation end-products (AGEs) in the pathogenesis of diabetic cardiomyopathy. We investigated whether type 2 diabetes and the metabolic syndrome are associated with altered myocardial structure, microvasculature, and expression of AGEs and receptor for AGEs (RAGE) in men with coronary artery disease.Methods: We performed histological analysis of left ventricular biopsies from 13 control, 10 ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by grants from the National Health and Medical Research Council of Australia and from the National Heart Foundation of Australia. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program. D.J. C. (Grant ID 395508) and D.J. K. (Grant ID 566867) are recipients of Senior Research Fellowships from the National Health and Medical Research Council of Australia. We thank Laura Stamp, Robyn Kelly, Kim Hewitt, and Francoise Campbell for assistance with histology.